Downloads on this page are provided to academic and non-commercial users under the PyRosetta Software Non-Commercial License Agreement. This license applies to all downloads on this page.

Use for commercial purposes requires purchase of a separate license. (This includes fee-for-service work by academic users.) Please see here or email for more information.

PyRosetta is available for Intel-based Mac's (64-bit OS X v10.5+) and M1-arm64 Mac's as well as on Linux (64-bit Red Hat and 64-bit Ubuntu) platforms in continuous release versions (usually we have a fresh builds available daily). Running on Windows-10 (thought Unix layer) is are also supported. In order to run PyRosetta you will need to use Python-3.6 or later. If you would like to build PyRosetta from source please see relevant section in [Documentation]  page. 

Please use our forums for technical support and assistance or if you have any questions or problems with installing PyRosetta.

PyRosetta binaries is available in three different forms: (a) as Python packages, (b) Python-wheel packages and (c) as Conda packages. We also provide auxiliary pyrosetta-installer pip package to help install PyRosetta. Using pyrosetta-installer package is a recommended way to install PyRosetta.

PyRosetta Build Information

Release - Speed optimized build, use it for production runs.

MinSizeRel - Build optimized to reduce memory footprint. Use this build with low-memory systems.

Debug - Binaries compiled in debug mode with additional asserts enabled and with debug-info compiled-in. Use this build for debugging.

Python-x.x versions - PyRosetta build for specific Python version

Installing PyRosetta using pip and pyrosetta-installer package

Due to size of PyRosetta it is not a good a fit PyPI package however we provide special pyrosetta-installer package that have pyrosetta_install() function which should perform PyRosetta install for most of the supported platforms. To use this install method run:

pip install pyrosetta-installer 

python -c 'import pyrosetta_installer; pyrosetta_installer.install_pyrosetta()'

The install_pyrosetta function also takes few optional arguments:

For up-to-date list of supported options see

Installing dependencies packages needed for PyRosetta Distributed framework

pip install pyrosetta-distributed 

For up-to-date list of supported options please see

Latest PyRosetta Versions, Python and Python-wheel Packages:

[US East coast mirror] [US West coast mirror]

Windows 10:  

PyRosetta-4 Linux build work natively thought Win10 Linux layer. For installation details please see: Instructions for Installing PyRosetta on Windows 10 

PyMOL-RosettaServer scripts

[PyMOL-RosettaServer.python2] [PyMOL-RosettaServer.python3]



RosettaCommons Conda Channel 

The RosettaCommons conda channel provides conda packages for each weekly releases. Currently PyRosetta.release packages for Python 3.6, 3.7, 3.8 and 3.9 provided for both Mac and Linux platforms. Note that when possible we intend to keep all released packages available (i.e old releases packages will not be deleted), so it should be safe to publish your results and use explicit PyRosetta version to ensure reproducibility. To use RosettaCommons channel edit your local ~/.condarc and add into your channels list. Then run conda install pyrosetta (or conda install pyrosetta=<version> if you want to install specific version of PyRosetta).

Example ~/.condarc for WEST cost (if unsure use this mirror)



# some of PyRosetta versions might require conda-forge channel, uncomment line below if you want to use it

# - conda-forge

- defaults

 Example ~/.condarc for EAST cost:



# some of PyRosetta versions might require conda-forge channel, uncomment line below if you want to use it

# - conda-forge

- defaults

Other PyRosetta builds

Our release archive: [full list of available releases

Installation Instructions

GNU/Linux and Mac OS X

    PyRosetta is distributed as a standard Python "distutils" package, which is compatible with most Python package management systems. (Though due to licensing issues, it is not available through pip.) There are two major ways to install PyRosetta: either into your standard system Python, or using a Python environment manager. Installation into the system Python is easier and makes PyRosetta available at all times, though it makes upgrading PyRosetta more difficult and may require administrator access. Using an environment manager is more flexible and permits installation as a normal (non-admin) user, but requires more effort in understanding the system. 

    In addition to standard '' package we provide Python wheel packages (use '.wheel' download links). Wheel package significantly reduce install time but requires `pip` to be present on your system. To install PyRosetta from wheel use `pip install pyrosetta-<version>.whl` command.

System-wide install (using system Python):

Installation with an environment manager:

Before beginning, be sure that your desired environment manager (e.g. conda or virtualenv) is installed in your system. Please see tutorials for the corresponding environment manager to learn how to install and use them.