Welcome to PyRosetta!

PyRosetta is an interactive Python-based interface to the powerful Rosetta molecular modeling suite. It enables users to design their own custom molecular modeling algorithms using Rosetta sampling methods and energy functions.

PyRosetta was created at Johns Hopkins University by Jeffrey J. Gray, Sergey Lyskov, and the PyRosetta Team. Its development is supported by:


 NSF Grant 0846324.

NIH grant R01-GM73151.




Recent news

  • PyRosetta builds for Python-3.8, Python wheel's and PyMOL-Rosetta server packages is now available
    - PyRosetta Release/MinSizeRel/Debug builds for Python-3.8 is now available for Mac, CentOS and Ubuntu platforms and as Conda builds.
    - We now also now provide Python wheel packages for Python 3.6, 3.7 and 3.8 version.
    - PyMOL-Rosetta scripts for both Python-2 and Python-3 can be directly downloaded from our download page.
    Download it here: http://www.pyrosetta.org/dow  
    Posted Jun 24, 2020, 2:24 PM by Sergey Lyskov
  • PyRosetta builds for Python-3.7 is now available
    PyRosetta Release/MinSizeRel/Debug builds for Python-3.7 is now available for Mac, CentOS and Ubuntu platforms and as Linux/Mac Conda builds. Download it here: http://www.pyrosetta.org/dow  
    Posted Jun 3, 2019, 10:55 AM by Sergey Lyskov
  • PyRosetta builds for Conda is now available
    PyRosetta Python-3.6 binary packages for Conda is now available for both Mac and Linux environments. Please see download instructions at http://www.pyrosetta.org/dow
    Posted Apr 23, 2019, 11:45 AM by Sergey Lyskov
  • PyRosetta builds for Python-3.6 is avalible
    PyRosetta binaries build with Python-3.6 support is now available for ScientificLinux, Ubuntu and Mac platforms in all varieties: debug, release and min-size-release. New packages available as tar archives as well as Git repositories checkouts. Download it here: http://www.pyrosetta.org/dow 
    Posted Sep 19, 2017, 3:14 PM by Sergey Lyskov
  • New Edition of PyRosetta Workshops Available for PyRosetta4!
    The 3rd edition of The PyRosetta Interactive Platform for Protein Structure Prediction and Design is available for purchase through Amazon. [Purchase]
    Posted Mar 27, 2017, 10:11 AM by Rebecca Alford
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